DAS181 Blocks Respiratory Syncytia Virus Infection of Hep-2 Cells
نویسندگان
چکیده
منابع مشابه
Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells.
Earlier reports have shown that herpes simplex virus 1 (HSV-1) mutants induce programmed cell death and that wild-type virus blocks the execution of the cell death program triggered by expression of viral genes, by the Fas and tumor necrosis factor pathways, or by nonspecific stress agents. In particular, an earlier report from this laboratory showed that the mutant virus d120 lacking the genes...
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BACKGROUND Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised (IC) hosts. DAS181, a novel sialidase fusion protein inhibitor, seems to be effective against PIV in vitro and in vivo; its use in IC children has not been evaluated. METHODS Patients were diagnosed with PIV infection using a quantitative reverse transcription-polym...
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Real-time tracking of virus invasion is crucial for understanding viral infection mechanism, which, however, needs simple and efficient labeling chemistry with improved signal-to-noise ratio. For that purpose, herein we investigated the invasion dynamics of respiratory syncytial virus (RSV) through dark-field microscopic imaging (iDFM) technique by using Au nanoparticles (AuNPs) as light scatte...
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Respiratory syncytial virus (RSV) grown in HEp-2 cells in the absence of calcium did not induce cell fusion and syncytium formation. Although the infected cells contained viral antigens, the cytopathic effect (giant cell formation) typical for RSV was not observed in calcium-free cultures. Infectious virus yield was also slightly reduced (less than a one log10 reduction) in the absence of calci...
متن کاملExpanding the armamentarium against respiratory viral infections: DAS181.
Respiratory viral infections result in significant morbidity and mortality in adults and children globally. Influenza, alone, is responsible for seasonal epidemics resulting in 3–5 million severe infections and 250 000–500 00 deaths per year [1]. Additionally, influenza results in milder infections which significantly reduce productivity among otherwise healthy adults, resulting in approximatel...
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ژورنال
عنوان ژورنال: Journal of Antivirals & Antiretrovirals
سال: 2016
ISSN: 1948-5964
DOI: 10.4172/jaa.1000137